C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line

The latest paper in now available online in Molecular Cell. Abstract In the male mouse germ line, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide DNA methylation of young active transposons through SPOCD1. However, the underlying mechanisms of SPOCD1-mediated piRNA-directed transposon methylation and whether this pathway functions to protect the human germ […]